Moreover, a potential splicing regulatory network was established and after multiple-database validation, we supposed that the signaling axis of HSPB1 up-regulating the PIP5K1C − 46,721 − AT (P < 0.001) might mediate the tumorigenesis, progression and metastasis of PRAD via the key members of Alzheimer’s disease pathway (SRC, EGFR, MAPT, APP and PRKCA) (P < 0.001). Here, PRKCA is linked to early-onset autosomal dominant Alzheimer disease.