According to the results, PIP5K1C-46721-AT was extremely co-expressed with the pathway of Alzheimer’s disease pathway (R = 0.480, P < 0.001); RGS11-32,858-AT was up-regulated in amyotrophic lateral sclerosis pathway (R = 0.470, P < 0.001); SLC9B1-70,158-AT was less expressed in pathway of oxidative phosphorylation pathway (R = − 0.440, P < 0.001); SLC9B1-70,159-AT was significantly correlated with oxidative phosphorylation pathway (R = 0.440, P < 0.001). This evidence concerns the gene RGS11 and early-onset autosomal dominant Alzheimer disease.