Ten of the 11 genes with five or more connections (ARID1A, CHD3, CHD4, KMT2A, MED13L, SMARCA4, SMARCB1, SMC1A, SMC3 and TRRAP) functioned in chromatin remodelling, a process that is essential to cellular differentiation and maintenance and has been implicated across a range of neurological disorders (20,21). This evidence concerns the gene SMARCA4 and nervous system disorder.