HMGCS2 and heart failure: Among the top upregulated genes in response to HFD/STZ-induced diabetes within each cell population were transcripts for Pdk4, Angptl4, Txnip, Postn, Hmgcs2, and Ucp3, of which several have been previously involved in heart failure (Yoshioka et al., 2007; Lang et al., 2018; Sheeran et al., 2019; Koenig et al., 2022).