The genes that were most highly expressed in only a single-cell type were Gm20658 (fibroblasts), Ucp3 (cardiomyocytes), Spock2 (endocardial cells), Irf7 (endothelial cells), and Ifi206 (macrophages), of which Ucp3 and Irf7 were involved in heart failure and pathological cardiac hypertrophy (Jiang et al., 2014; Senatus et al., 2020). The gene discussed is SPOCK2; the disease is heart failure.