ITGB1 and diabetes mellitus: The PPI network of the upregulated uni-DEGs and immunostaining results indicate the key role of Itgb1 of Hrchi fibroblasts in diabetic myocardial fibrosis (Figure 6D, n = 6 mice per group; Figure 6—figure supplement 2, two-sided Wilcoxon rank-sum test, FDR ≤0.05, log2FC ≥0.36).