NCOA4 siRNA weakened the effects of Sch B on iron deposition and HSCs senescence.<h4>Conclusions</h4>Sch B could ameliorate hepatic fibrosis through the promotion of activated HSCs senescence, which might be attributed to its induction of NCOA4-mediated ferritinophagy and subsequent iron overload. The gene discussed is NCOA4; the disease is Hepatic fibrosis.