As a nutrient sensor, O-GlcNAcylation is pivotalin the progression of cancer, and O-GlcNAcylationoccurs on a series of transcription factors (such as SP1, c-MYC, p53)that regulate the initiation of cancer-related biological processes.183,184O-GlcNAcylation changes in breast, colorectal,lung, ovarian cancers were systematically quantified, and some O-GlcNAcylated proteins were differentially regulated ineach type of cancer.185−187 For example, in lung cancer, it was reportedthat O-GlcNAcylation of SAM68 was related to cancermigration and invasiveness. The gene discussed is TP53; the disease is cancer.