For example, Myc proto-oncogene protein(c-MYC) is a critical transcription factor in cancer progression.It was reported that c-MYC can be O-GlcNAcylated,and the modification stabilized the protein in prostate cancer cells.94,95 Moreover, O-GlcNAcylation promoted the traffickingof NOTCH1 to the cell surface and mediated its stability.96 This evidence concerns the gene MYC and cancer.