To entangle the underlying mechanism of FADS2 in reducing steatosis, Hendriks et al. analyzed lipidomics of FADS2WT, FADS2−/− and FADS2OE organoids, and found the FADS2OE reduced total TAG content and metabolized from newly synthesis short chain TAGs to long chain PUFAs. This evidence concerns the gene FADS2 and steatosis.