Cox proportional hazards models indicated that UVSD (HR 1.674 (95% CI 1.044–2.684), p=.030) and UVCV (HR 2.509 (95% CI 1.519–4.141), p<.001) (higher versus lower) were positively associated with all-cause mortality in univariate analyses, while after adjusting for age, CVD, diabetes, vascular access, CKD etiology, hemoglobin, serum albumin, serum phosphorus, and serum iPTH, only higher UVCV remained significantly associated with all-cause mortality in patients receiving HD (HR 2.55 (95% CI 1.397–4.654), p=.002) (Figure 4(A,B)). The gene discussed is ALB; the disease is chronic kidney disease.