It has been reported that Theobromine is a natural stimulant and vasoactive alkaloid that can prevent ischemic injury [52]; Cyclo gly-pro has a neuroprotective effect on hypoxic-ischemic brain injury in rats [53]; HPX is a rate-limiting enzyme that eliminates excessive free hemoglobin during ischemic stroke [54]; ApoA1 is the main transport protein for high-density lipoprotein macromolecules and significantly reduces the infarct volume and the transformation rate of hemorrhage by decreasing neutrophil recruitment [55]. Here, HPX is linked to ischemic stroke.