At the same time, surgery, as a kind of trauma treatment, is also a major source of stress after surgery, in which inflammatory factors will also change significantly under the stress of surgery, while IL-6 and CRP, often as stress indicators of pain, have also been proved to play an important role in the diagnosis and treatment of depression, which is considered to induce immune response in the human body under stress [19]. This evidence concerns the gene IL6 and depressive disorder.