ATXN2L and irritable bowel syndrome: Treatment with otilonium bromide, which blocks L-type calcium channel, reduced abdominal pain frequency in a randomized placebo-controlled trial 355 patients with IBS (91 IBS-D, 110 IBS-C, 154 IBS-M);99 and treatment with pregabalin, which binds the α2δ subunit on voltage-dependent calcium channels, has been shown to reduce pain and increase sensory thresholds in IBS and especially in patients with IBS-D.100,101