NOTCH3 and CADASIL: A mutation in which a part of the NOTCH3 intron 3 branch point site was deleted, causing abnormal splicing, has been found in a family with late-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and a leukoencephalopathy (CADASIL) phenotype, suggesting an association between this variant and the pathologically confirmed CADASIL phenotype111.