TMPRSS4 and non-small cell lung carcinoma: In addition, Villalba et al.74 recently performed large-scale analyses of five public NSCLC datasets and identified a synthetic lethal interaction between TMPRSS4 and DDR1; TMPRSS4/DDR double knockdown resulted in cell cycle arrest and apoptosis; furthermore, cells became highly sensitized to cisplatin in vitro, and tumors regressed in vivo.