Subsequently, we examined the effect of SAMHD1 on cell migration using in vitro wound-healing assays and found that SAMHD1 knockdown suppressed cell migration in both the ACHN and SN12C cell lines (Fig. 2b), whereas SAMHD1 overexpression significantly promoted the migration of ccRCC cells (Fig. 2c). The gene discussed is SAMHD1; the disease is nonpapillary renal cell carcinoma.