Moreover, Lypd8 expression has been found to be significantly decreased in colon cancer tissues, and the activities of the IL-6/signal transducer and activator of transcription 3 (STAT3) and TNF-α/NF-κB inflammatory signaling pathways were increased compared to those in precancerous and normal tissues70. The gene discussed is NFKB1; the disease is malignant colon neoplasm.