Recently, it was demonstrated that the combination of oncolytic herpes simplex 1-based-expressing human IL15/IL15Rα sushi domain fusion protein (named OV-IL15C) and off-the-shelf epidermal growth factor receptor (EGFR)-CAR NK cells triggers strong antitumor responses in GBM (Ma et al., 2021). The gene discussed is EGFR; the disease is glioblastoma.