evaluated a unique combination of novel adenovirus-cycE (a novel E1b-deleted oncolytic adenovirus-cycE, in which Ad E1a gene is driven by the cyclin E promoter) with rapamycin, an autophagy inducer and first-line chemotherapy drug, suggesting that combination of autophagy inducer rapamycin and oncolytic adenovirus enhances antitumor effect of cancer cells (Cheng et al., 2013). The gene discussed is DHTKD1; the disease is cancer.