In addition, at 12 hours post infection, cleavage fragments of caspase-8 (p18) was not detected in the infected group compared with the uninfected group, indicating that caspse-8 was not involved in the cleavage of GSDMD (Figure 2B).These results suggested that caspase-1 and caspase-11 may play an important role in C. trachomatis clearance mediated by GSDMD activation. The gene discussed is CASP8; the disease is infection.