SIRT3 and brain injury: Adiponectin (APN), a 30 kDa adipocytokine, has been found to protect neurological function following traumatic brain injury, and PRDX3, a critical antioxidant enzyme in mitochondria, has been identified as a significant downstream target of the APN/SIRT3 axis to reduce oxidative damage following TBI (Zhang S. et al., 2022).