In addition, m6A modified genes related to monocyte infiltration were also clinically important in GDM, including CD81, CFH, FABP5, GBP1 etc. (Du et al., 2022b) Decreased level of METTL4 was found in placentas from GDM patients, and the m6A levels of BAMBI, INSR and IRS1 which are GDM-related genes were also significantly decreased, with the same change in mRNA and protein levels (Wang et al., 2021). The gene discussed is IRS1; the disease is gestational diabetes.