Several studies have shown that Aβ downregulates response element binding protein (CREB)-mediated transcription (España et al., 2010; Pugazhenthi et al., 2011), that CREB-mediated gene expression is impaired in AD brains, and that CREB-regulated BDNF levels are reduced.BDNF is the most widely distributed neurotrophic growth factor in the CNS and plays an important role in brain regions involved in learning, memory, and higher cognitive functions (Bekinschtein et al., 2008). Here, CREB1 is linked to Alzheimer disease.