MAPT and Brain atrophy: Jeon et al. (2011) found that early inhalation of SHXW EO improved CI caused by Aβ (1–42) and inhibited Aβ-induced Tau phosphorylation by suppressing the activation of JNK and p38 in the brain. Lee et al. (2021) fed AD mice Induced by Aβ1-40 with the same essential oil content of Litsea cubeba Persoon Powder, and showed that it reduced P-Tau content and Aβ plaques, resulting in about 3–8% reduction in brain atrophy.