Mental-tranquilization, Invigorating The Brain And Ichihing FruitReduce the levels of inflammatory factors TNF-α, IL-6, IL-1β in serum by inhibiting the activation of astrocytes and microglia, reduce the generation of Aβ and amyloid plaques and increase the Ach content in the cortex, thereby protecting neurons and preventing AD. Here, IL1B is linked to Alzheimer disease.