APP and Alzheimer disease: Furthermore, we observed amelioration of the spatial learning performance in AD model rats induced by Aβ25 − 35, APP/PS1, and SAMP8 mice (Nie et al., 2016; Lv et al., 2020), and this effect may be related to a decrease in the generation of Aβ by regulating APP, α-secretases (ADAM10 and ADAM17), and BACE1 (Huang J. et al., 2019).