MAPT and Alzheimer disease: Kinesin-I heavy chain (KIF5B) and histone deacetylase (HDAC) are involved in tau homeostasis in AD (Simões-Pires et al., 2013; Selvarasu et al., 2022), which relates to the ubiquitin–proteasome system primarily clearing pathological tau and the autophagy–lysosome pathway degrading tau at the late stage of the formation of neurofibullary tangles (NFTs) (Rawat et al., 2022).