The kidney is the most important excretory organ of the body, and some studies have reported that chronic kidney disease (CKD) can lead to elevated plasma levels of Aβ42, Aβ40, p-tau181 and NfL (Mielke et al., 2022; Syrjanen et al., 2022), which may due to the decreased renal clearance (Cheng et al., 2020). The gene discussed is NEFL; the disease is chronic kidney disease.