Quantification of co-localized signals showed that pTDP-43 co-localized with the cytoplasmic TDP-43 staining (Figure 1E), in both control and ALS patients’ retina giving similar Manders coefficients (ALS: 0.82 ± 0.02, n = 6 patients; controls: 0.81 ± 0.05, n = 6 individuals). Here, TARDBP is linked to amyotrophic lateral sclerosis.