TARDBP and amyotrophic lateral sclerosis: Nuclear staining of TDP-43 gave a strong and diffuse staining in all retinal layers in both ALS patients and control subjects (Figures 1A,B; ALS: 4.6 ± 0.3, n = 57/7 fields/individuals; controls 4.4 ± 0.4, n = 50/6 fields/individuals; p = 0.9).