CASP3 and amyotrophic lateral sclerosis: In particular, we found that the percentage of RGCs positive for cleaved Caspase-3 in each field of view (FOV) examined was increased compared to age matched controls (ALS: 33 ± 6%, n = 50/5 fields/individuals; CTRL: 18 ± 3%, n = 51/6 fields/individuals; p < 0.05; Figure 3B).