TARDBP and amyotrophic lateral sclerosis: We analyzed the colocalization of TDP-43 with its phosphorylated form pTDP-43 at Ser409 (Figure 1D), because in ALS motor neurons, insoluble pathological inclusions of TDP-43 consist mainly of cytoplasmic deposition of C-terminally phosphorylated TDP-43 (Neumann et al., 2009).