SQSTM1 and amyotrophic lateral sclerosis: Staining of p62, evaluated as p62 signal integrated density in a region of 400 μm2, was significantly higher in ALS patients (ALS: 5.4×105 ± 0.8×105, n = 59/7 fields/individuals) compared to controls (controls: 1.7 × 105 ± 0.3 × 105n = 65/6 fields/individuals; p < 0.01; Figure 2B).