In particular, for ALS cases, typical motor neuron inclusions are positive for ubiquitin/p62, ubiquilin-2, SOD1 (Soldatov et al., 2021), TDP-43, and pTDP-43 (Arai et al., 2006; Neumann et al., 2006). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.