Other mechanisms could, indeed, be involved, including increased synthesis or turnover, altered axonal transport, active secretion, or exosome release (Gafson et al., 2020; Verde et al., 2021); we cannot even exclude that NF alterations play a more “proximal” and active role in ALS pathogenesis, as suggested by some experimental findings (Williamson et al., 1998). This evidence concerns the gene NFASC and amyotrophic lateral sclerosis.