DLG4 and synucleinopathy: Considering the fundamental role of scaffolding proteins in regulating post-synaptic retention of iGluRs, we subsequently measured the post-synaptic levels of the most abundant PSD-associated protein, PSD-95, and the NMDAR-scaffolding partner, Rph3A, which were recently demonstrated to contribute to early synaptic dysfunction in experimental models of synucleinopathies induced by αSyn-PFF (Stanic et al., 2015; Ferrari et al., 2022).