To evaluate whether IL‐1β could affect the tumor‐killing capacity of T cells via modulating tumor cells, SKOV3 cells that express neoantigen New York esophageal squamous cell carcinoma‐1 (NY‐ESO‐1) higher, compared to the other two ovarian cancer cell lines A2780 and OVCAR8 (Figure S1E), were pretreated with IL‐1β or without and then co‐cultured with NY‐ESO‐1 CAR‐T cells at a ratio of 1:2 to mimic the tumor‐specific killing of cytotoxic T cells. The gene discussed is IL1B; the disease is esophageal squamous cell carcinoma.