To investigate whether tumor‐infiltrated Mφ could produce an immunosuppressive microenvironment in ovarian cancer, a representative “cold” tumor, we determined the CD68 expression, a classic marker of Mφ, in clinical tumor specimens of high‐grade serous ovarian cancer (HG‐SOC) patients with immunohistochemistry (IHC) staining (n = 41). The gene discussed is CD68; the disease is ovarian carcinoma.