Viral pathogen recognition pathways such as Toll-like receptor signaling through MyD88, retinoic acid-inducible gene I (RIG-1)/melanoma differentiation-associated protein 5 pathways, and the antiviral type I interferon (IFN α/β) response and the complement cascade are also highlighted in the COVID-19 gene signaling network. This evidence concerns the gene IFIH1 and COVID-19.