The coronavirus/COVID-19 disease pathway consists of anti-viral detection via the toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I) pattern recognition receptor pathways, activation of the NLRP3 inflammasome, and signaling through the pro-inflammatory cytokines IL-6, JAK/STAT, PI3K, and MAPK signaling cascades, and activation of the transcription factor NF-KB. The gene discussed is RIGI; the disease is COVID-19.