In conclusion, the present study revealed a high frequency of AT among euthyroid prepubertal girls with PA, and while waiting for larger studies to confirm our findings, screening PA girls for autoimmune thyroid disease would be justifiable. Girls with PA and concomitant AT had higher TSH levels, cortisol response post-SDSST and insulin levels during OGTT compared to those with PA alone. This evidence concerns the gene INS and ataxia telangiectasia.