COX17 and acute myeloid leukemia: ,23 Meanwhile, Cu transporters COX17 participates in the delivery of Cu from the mitochondrial inter-membrane space to cytochrome c oxidase (CcO), the terminal enzyme in the mitochondrial energy-transduction respiratory chain, and studies have shown that Cu chaperone COX17 regulates the properties and differentiation of acute myeloid leukemia stem cells by controlling the level and distribution of mitochondrial Cu.24