After two cycles of chemo-immunotherapy, her CT scan at 6 weeks showed an increase in mediastinal and bilateral hilar/infrahilar adenopathy and numerous lung lesions except for a single lesion within the right lower lobe (Supplementary Fig. S4A); however, we found a prompt substantial increase of PB CX3CR1+ CD8+ T cells and the CX3CR1 score (Supplementary Fig. S4B). This evidence concerns the gene CX3CR1 and lymphatic system disorder.