To investigate the significant role of CTNNB1 in the etiology and progression of NDDs, we conducted a comprehensive literature search in PubMed from 1/1/2002 to 11/31/2022, utilizing the following search terms: [(Ctnnb1) OR (CTNNB1) OR (β-catenin)] AND {[(NDD) OR (neurodevelopmental disorder)] OR [(ASD) OR (autism spectrum disorder)] OR [(ID) OR (intellectual disability)] OR [(SCZ) OR (schizophrenia)]}. The gene discussed is CTNNB1; the disease is autism spectrum disorder.