To be specific, CASC5, BCL2, and CDK4 levels were decreased by overexpressed miR-133a-3p, and BAX level was increased by miR-133a-3p, suggesting the promotive effects of miR-133a-3p on CRC cell apoptosis, further proving the results in Figure 3b. This evidence concerns the gene KNL1 and colorectal carcinoma.