In this study it was found that animals with MS developed kidney damage characterized by hypertrophy that was determined by kidney weight/total body weight ratio, (Control: 2.0 ± 0.02, MS: 2.5 ± 0.02 g); urine protein excretion (MS: 120 ± 5.3 mg/24 hr vs 20.6 ± 2.6 mg/24 hr control), and oxidative stress characterized by a decrease in the activity of anti-oxidant enzymes catalase and superoxide dismutase (Figures 5a and 5b). The gene discussed is CAT; the disease is myeloid sarcoma.