Comparing transcriptional and translational efficiency for indicating SDHB germline mutation, Chunzhang Yang and colleagues found that SDHB-related PCC/PGL tumors demonstrated unreduced mRNA expression but significantly declined protein expression than non-SDHB PCC/PGL (37), and most SDH-mutated tumors were negative for SDHB IHC, while non-SDH related tumors nearly all showed expression of SDHB by IHC (25). This evidence concerns the gene SDHB and adrenal gland pheochromocytoma.