Collectively, except for the five genes (COL5A2, ACPP, FOSB, SH3BGRL, and ST7) that function as important biomarkers in PCa, the significant role of another five genes (IFRD1, TUBA1A, CFAP69, TMEM38B, and MANEA) in PCa is still not demonstrated, which needs further investigation. Here, IFRD1 is linked to posterior cortical atrophy.