With the optimal lambda value of 0.025 based on minimal mean square error (Figure 3B), 10 genes [i.e., IFRD1, COL5A2, TUBA1A, CFAP69, TMEM38B, ACPP, MANEA, FOSB, SH3BGRL, and suppressor of tumorigenicity (ST7)] were identified as significantly enzalutamide-induced genes that are related to the prognosis of PCa RFS. Here, FOSB is linked to posterior cortical atrophy.