Meanwhile, IFRD1, COL5A2, TUBA1A, and CFAP69 served as the risk factors (coefficient > 0), and TMEM388, ACPP, MANEA, FOSB, SH3BGRL, and ST7 served as protective factors (coefficient < 0) in PCa (Figure 3C). Here, IFRD1 is linked to posterior cortical atrophy.