Thirty-one candidate genes were screened and selected by lasso Cox regression model, and 10 significant enzalutamide-induced genes (IFRD1, COL5A2, TUBA1A, CFAP69, TMEM388, ACPP, MANEA, FOSB, SH3BGRL, and ST7) related to PCa RFS were remained. Here, IFRD1 is linked to posterior cortical atrophy.