This genotype is also present in the euthyroid father, but not in the mother who is carrier of the heterozygous Ala-14/16 FOXE1. The co-segregation of an additional non-FOXE1 defect together with the FOXE1 p.L107V variant in all the 5 athyreotic siblings has a low likelihood and this probability would be further lowered if we consider the other two siblings with a CH-like phenotype that died before this study. This evidence concerns the gene FOXE1 and cyclic hematopoiesis.