The heterogeneity was observed between PCOS and serological indicators for CKD by the IVW analysis: fibroblast growth factor 23 (Q = 5.593, P= 0.848), creatinine (Q =12.209, P = 0.348), cystatin C (Q = 24.178, P= 0.012), estimated glomerular filtration rate (Q = 14.978, P= 0.092), β2-microglobulin (Q =1.172, P = 0.760), urinary albumin-to-creatinine ratio (Q = 33.101, P<0.001). Here, CST3 is linked to chronic kidney disease.