NOD2 and rheumatoid arthritis: We found that BAX, CASP1, CASP3, CASP4, CASP5, CHMP2B, CHMP3, HMGB1, IL18, IL1A, AIM2, NLRC4, NOD2, TNF, and GZMA were overexpressed in RA patients compared to healthy controls (Figures 1A, B).