reviewed 164 cases of Cushing’s syndrome and 77 cases of pheochromocytomas and found only two cases of ectopic ACTH production from adrenal medullary lesions (one case of pheochromocytoma and one case of adrenal medullary hyperplasia) (31). The gene discussed is POMC; the disease is hereditary pheochromocytoma-paraganglioma.