For instance, 14 genes, namely Cd53, Laptm5, Nckap1l, C3ar1, Hck, Mpeg1, Cybb, Iqgap1, Dock2, Plek, Fcer1g, Igsf6, Ptprc and Havcr2, which were strongly upregulated in mouse fed with CDAHFD chow (Figure 7D), supporting the notion that these hub genes were also activated during progression of mouse NASH model. The gene discussed is C3AR1; the disease is metabolic dysfunction-associated steatohepatitis.