Intriguingly, previous reports examining human NASH livers using single-cell RNA sequencing reported that M-Mac-1 included three genes, HLA-DRA, HLA-DQA2 and HLA-DQB2 (63), which was related to NAFLD loci (57, 64, 65). This evidence concerns the gene HLA-DQB2 and metabolic dysfunction-associated steatotic liver disease.