Those key genes in MergeCohort_Turquoise module including CD53, LCP1, LAPTM5, PTPRC and SRGN expressed by distinct immune cells such as microphages, NK cells, T cells, dendritic cells and B cells, and most of them, namely FGL2, HCK, MPEG1, CYBB, CSF1R, IGSF6, CPVL and HLA-DRA were mainly expressed by macrophages, dendritic cells (Figure 8C; Supplementary Figure S3), which indicated that the macrophages and dendritic cells play an important role in the pathogenesis of NASH. The gene discussed is IGSF6; the disease is metabolic dysfunction-associated steatohepatitis.