PKLR and metabolic dysfunction-associated steatotic liver disease: Similarly, previous biological network analysis identified cholesterol synthesis genes in human NAFLD (e.g., FDFT1, NSDHL, IDI1, SQLE, MVD, HMGCS1 and HMGCR) and fatty acid metabolism genes (e.g., Fasn, Thrsp and Pklr) in NAFLD mouse model that were also reported to be deregulated by (47) and (18), respectively.