HMGCS1 and metabolic dysfunction-associated steatohepatitis: Our data found Grey60 module that was significantly upregulated in NASH, enriched in the lipid metabolism pathways, encompassing hub genes related to cholesterol metabolism (FDFT1, NSDHL, IDI1, SQLE, MVD, HMGCS1, HMGCR and LSS) as well as fatty acid metabolism (FASN, ELOVL6, FADS1, FADS2, ACACA, ELOVL6, PKLR and THRSP) (Figure 4C).