We observed that RFX5 and ILF3, an important transcriptional factor mainly expressed in the liver, upregulated from mild to advanced NASH, regulates the expression of genes involved in antigen processing and presentation of exogenous peptide antigen via MHC class II, including HLA-DQB2, HLA-DOA, HLA-DMA, HLA-DQA1, HLA-DMB, HLA-DPB1, HLA-DPA1 and HLA-DRA. The gene discussed is HLA-DOA; the disease is metabolic dysfunction-associated steatohepatitis.