Ins2, Hkdc1, and Pik3cd were singled out as genes that were expressed to the highest extent in EpiC compared to Mock transfected cells in the Type II Diabetes mellitus pathway while Itpr3 and Adcy7 were expressed in the Insulin expression pathway from KEGG analysis (Figure 7C) and therefore may represent the next target genes to be examined in the course of alpha cell reprogramming. This evidence concerns the gene ITPR3 and type 2 diabetes mellitus.