Ins2, Hkdc1, and Pik3cd were singled out as genes that were expressed to the highest extent in EpiC compared to Mock transfected cells in the Type II Diabetes mellitus pathway while Itpr3 and Adcy7 were expressed in the Insulin expression pathway from KEGG analysis (Figure 7C) and therefore may represent the next target genes to be examined in the course of alpha cell reprogramming. The gene discussed is HKDC1; the disease is type 2 diabetes mellitus.