The result showed methylation markers at five loci including thioredoxin-interacting protein (TXNIP), ATP-binding cassette subfamily G(ABCG1), phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1), suppressor of cytokine signaling 3(SOCS3) and sterol regulatory element binding transcription factor 1(SREBF1) were related to the increased risk for T2DM. This evidence concerns the gene PHOSPHO1 and type 2 diabetes mellitus.