The result showed methylation markers at five loci including thioredoxin-interacting protein (TXNIP), ATP-binding cassette subfamily G(ABCG1), phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1), suppressor of cytokine signaling 3(SOCS3) and sterol regulatory element binding transcription factor 1(SREBF1) were related to the increased risk for T2DM. Here, SOCS3 is linked to type 2 diabetes mellitus.