Several miR-132 target genes were identified and many are also important in neurodegenerative diseases, such as BACE1, APP, SIRT1, acetylcholinesterase (ACHE), nitric oxide synthase 1 (NOS1), and mitogen-activated protein kinase (MAPK1; Miyazaki et al., 2014; Salta and De Strooper, 2017; Qu et al., 2021; Zhang and Bian, 2021). The gene discussed is SIRT1; the disease is neurodegenerative disease.