Specifically, miR-34a can regulate several genes important for AD pathogenesis, such as sirtuin 1 (SIRT1), ADAM metallopeptidase domain 10 (ADAM10), triggering receptor expressed on myeloid cells 2 (TREM2), and BCL2 apoptosis regulator (BCL2; Nunomura and Perry, 2020). Here, SIRT1 is linked to Alzheimer disease.