NPC1 and anemia: Moreover, NPC1 has been demonstrated to have a role in hematopoiesis, with some NPC patients showing hematological defects such as thrombocytopenia, anemia and petechial rash and it was also observed in npc1 zebrafish morphants (Louwette et al., 2013), and angiogenesis has proved to be inhibited by alteration in cholesterol trafficking in NPC individuals (Lyu et al., 2018).