Through Western blot, Coinmunoprecipitation, Biotin switch assy, Immunofluorescence, and other experiments, Zhang et al. discovered that the interaction of nNOS-CAPON may result in the inhibition of the downstream ERK-CREB pathway in the Alzheimer’s disease mouse model, causing excitotoxicity and abnormal dendritic spine development, affecting cognitive function and triggering the progress of Alzheimer’s disease (Zhang Y. et al., 2018). Here, NOS1 is linked to Alzheimer disease.