CREB1 and Alzheimer disease: Through Western blot, Coinmunoprecipitation, Biotin switch assy, Immunofluorescence, and other experiments, Zhang et al. discovered that the interaction of nNOS-CAPON may result in the inhibition of the downstream ERK-CREB pathway in the Alzheimer’s disease mouse model, causing excitotoxicity and abnormal dendritic spine development, affecting cognitive function and triggering the progress of Alzheimer’s disease (Zhang Y. et al., 2018).