Recent studies have shown that CREB activation can play a harmful role in mediating drug addiction, anxiety-like behavior, insulin resistance, leukemia and other processes or diseases (Carlezon et al., 2005; Tregnago et al., 2016; Yoon et al., 2021) while CREB activation under different conditions can also improve muscle performance. The gene discussed is CREB1; the disease is Insulin resistance.