In cerebral ischemia rats model, the levels of p-ERK and p-CREB were significantly decreased, the activation of ERK/CREB pathway was significantly inhibited, and the expression of pro-inflammatory cytokine IL-6 and TNF-α was increased in post-stroke depression through sucrose preference test (SPT), forced swimming test (FST), tail suspension test (TST), western blot and Elisa experiments (Yin Q. et al., 2021). The gene discussed is MAPK1; the disease is brain ischemia.