LN gradually increased with the progress of HF stages (P < 0.01, Figure 3), age, ALT, AST, Tb, Scr, UN, TnI, NT-proBNP, HA also gradually increased with the increase of clinical stages, LVEF value tended to decrease with the progress of heart failure stages (P < 0.01), and there was no statistical difference in the history of type 2 diabetes, hypertension and gender (P > 0.01), as shown in Table 2. This evidence concerns the gene NPPB and heart failure.