Multivariate ordered Logistic analysis to different clinical stages of heart failure showed that LN (OR: 1.021, 95% CI: 1.011–1.030, P = 0.000), HA (OR: 1.011, 95% CI: 1.003–1.019, P = 0.005), NT-proBNP (OR: 1.000, 95% CI: 1.000–1.000, P = 0.017), LVEF (OR: 0.893, 95% CI: 0.865–0.923, P = 0.000), age (OR: 1.033, 95% CI: 1.006–1.061, P = 0.016), AST (OR: 1.006, 95% CI: 1.000–1.012, P = 0.048), and Tb (OR: 1.061, 95% CI: 1.027–1.097, P = 0.000) are all independent risk factors of severity of heart failure (P < 0.05), as shown in Table 3. This evidence concerns the gene MLPH and heart failure.