KEGG pathways were enriched in cytokine–cytokine receptor interaction, pathways in cancer, viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, chemokine signaling pathway, lipid and atherosclerosis, rheumatoid arthritis, AGE-RAGE signaling pathway in diabetic complications, amoebiasis, and TNF signaling pathway. The gene discussed is TNF; the disease is rheumatoid arthritis.