TNF and cancer: KEGG pathway analysis showed that the DEGs were significantly enriched in viral protein interaction with cytokine and cytokine receptor, NF-kappa B signaling pathway, cytokine–cytokine receptor interaction, chemokine signaling pathway, lipid and atherosclerosis, rheumatoid arthritis, AGE-RAGE signaling pathway in diabetic complications, amoebiasis, TNF signaling pathway, and pathways in cancer (Figure 4D).