We discovered that EMP1 (epithelial membrane protein 1) is significantly activated not only in CCl4 (carbon tetrachloride)-treated mice liver, but also in BDL (bile duct ligation)-induced mice liver fibrosis and even in human fibrotic liver tissues such as alcoholic hepatitis, NASH (nonalcoholic steatohepatitis), and also liver with advanced stage disease. Here, EMP1 is linked to Hepatic fibrosis.