The study in our cohort of 22 patients diagnosed with potentially malignant disorders and/or carcinomas starts from the idea of knowing the presence of the point mutation (exon 5 of the p53 gene as a transition from a T to a C base at codon 270 (c.T270C)) described in the article by S. Tang (14), which was taken as a reference for the first article published in this sample of patients (15). Here, TP53 is linked to carcinoma.