NOTCH1 and carcinoma: Although there is no consensus, except for the large variability in mutational influence, and given that in our sample of patients where 15 lesions with high-grade dysplasia, 2 lesions with high-grade dysplasia, and 5 carcinomas were diagnosed, no mutation for NOTCH1 was observed, it is concluded that further studies are required to understand not only the role of NOTCH1 in carcinogenesis, but also how it can act completely oppositely in the development and progression of HNSCC, in our case OSCC, as well as its signaling within the tumor microenvironment.