NOTCH1 and neoplasm: Despite the numerous roles that a mutation in the NOTCH1 gene can play in the etiopathogenesis of oral cancer, this study aims to search for NOTCH1 mutations in biopsied lesions diagnosed with potentially malignant disorders and / or oral carcinoma in a first cohort of 22 patients, in order to increase the sample in the future to find more exhaustively whether NOTCH1 could function as a molecular biomarker and, therefore, as a predictor of the risk of developing neoplasia in patients from the south of Spain who present lesions diagnosed as potentially malignant disorders of the oral cavity.