NOTCH1 and neoplasm: It appears that the activity that NOTCH develops as a tumor suppressor is closely related to the physiological function of NOTCH in the development and maintenance of the squamous epithelium (7), the loss of NOTCH1 produces changes in the signaling of other molecules that result in decreased cell differentiation, as well as an increase in the number of keratinocytes, variations in cellular senescence, and altered epithelial integrity (9).