Overexpression of miR-130a-3p abolished the role of YY1 in promoting microglial M2 polarization (Peng et al., 2022). Downregulation of miR-130a leads to the upregulation of the expression of IL-18, which aggravates thrombocytopenia in severe sepsis (Cui et al., 2016). This evidence concerns the gene IL18 and Sepsis.