In this commentary article, while we reviewed literature on various HICs in COVID-19 patients, preliminary laboratory data on gender differences in various HICs and associated clinical markers including, macrophage activation (serum ferritin), hematological dysfunction (neutrophil to lymphocyte ratio - NLR), coagulopathy (D-dimer), cytokinaemia (C-reactive protein: CRP), and liver inflammation (aspartate aminotransferase: AST) are also presented. The gene discussed is CRP; the disease is COVID-19.